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Tg(Prnp-MAPT*P301S)50Hiw
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-MAPT*P301S)50Hiw
Name: transgene insertion 50, Hiroki Iwashita
MGI ID: MGI:6286246
Synonyms: TPR50
Transgene: Tg(Prnp-MAPT*P301S)50Hiw  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-MAPT*P301S)50Hiw expresses 1 gene
 
Mutation detailsThe mouse prion promoter drives the expression of the longest human tau (MAPT) isoform (4R2N) in which proline is replaced by a serine at amino acid position 301 of the protein (P301S). Seven lines were established (16, 50, 56, 72, 82, 96, and 100). Line 50 is the highest expressing line. Western blot analysis confirmed increased expression in the hippocampus and showed that human tau is phosphorylated at T181, S202/T205, S214, S262, and S396. (J:213361)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:213361 Onishi T, et al., Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice. Neurosci Res. 2014 Mar;80:76-85
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory