Tg^M5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tg^M5Btlr
• Name: thyroglobulin; mutation 5, Bruce Beutler
• MGI ID: MGI:6285496
• Synonyms: Papua
• Gene: Tg Location: Chr15:66542606-66722570 bp, + strand Genetic Position: Chr15, 29.3 cM, cytoband D3-E
• Alliance: Tg^M5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 66,674,050 (v38) on chromosome 15, or base pair 3,297 in the GenBank genomic region NC_000081 encoding Tg. The mutation corresponds to residue 642 in the NM_009375 mRNA sequence in exon 5 of 48 total exons. The mutation results in an aspartic acid to glycine substitution of position 207 (D207G) in the thyroglobulin protein. (J:272523)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tg Mutation: 146 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3863

References

• Original: J:272523 Zhong X, et al., Mutagenetix entry for Papua. MGI Direct Data Submission. 2019
• All: 1 reference(s)