Kdm6b^tm1.1Masn
Targeted Allele Detail

Summary

• Symbol: Kdm6b^tm1.1Masn
• Name: KDM1 lysine (K)-specific demethylase 6B; targeted mutation 1.1, Masahide Asano
• MGI ID: MGI:6277129
• Synonyms: Jmjd3^delta18
• Gene: Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
• Alliance: Kdm6b^tm1.1Masn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247259
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 18 was replaced by a loxP flanked exon 18 and FRT-flanked neomycin resistance gene via homologous recombination. Cre-mediated recombination deleted exon 18, leaving the neomycin gene. (J:247259)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kdm6b Mutation: 65 strains or lines available

References

• Original: J:247259 Naruse C, et al., New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266
• All: 1 reference(s)