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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm2(CAG-Nr5a1)Fjd
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Franco J DeMayo
MGI ID: MGI:6275547
Synonyms: SF1LSL
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:269597
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm2(CAG-Nr5a1)Fjd expresses 1 gene
Mutation detailsThe targeting construct inserted into the locus a CAGGS promoter (consisting of the chicken beta-actin promoter and the cytomegalovirus enhancer), a loxP-STOP-loxP cassette, a cDNA encoding a tandem FLAG-Myc-tagged mouse Nr5a1 gene, and a polyadenylation signal. This creates a conditional-ready allele where the inserted gene is only expressed after the removal of the STOP cassette through cre-mediated recombination. (J:269597)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  504 strains or lines available
Original:  J:269597 Vasquez YM, et al., Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis. Mol Endocrinol. 2016 May;30(5):518-32
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory