Arnt2^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arnt2^em1Btlr
• Name: aryl hydrocarbon receptor nuclear translocator 2; endonuclease-mediated mutation 1, Bruce Beulter
• MGI ID: MGI:6272392
• Synonyms: Arnt2^R74C
• Gene: Arnt2 Location: Chr7:83895486-84059201 bp, - strand Genetic Position: Chr7, 48.35 cM
• Alliance: Arnt2^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: The CRISPR/Cas9 system and sgRNA 5'-ACAGTGAGATTGAGCGGCGC-3' was used to generate the mice. The CRISPR/Cas9 system generated a one-base pair replacement at c.373T>C (NM_007488.3). The mutation results in an arginine to cysteine change at amino acid 74 (p.R74C). (J:268298)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arnt2 Mutation: 37 strains or lines available

References

• Original: J:268298 Turer EE, et al., A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis. Dis Model Mech. 2018 Dec 18;11(12):dmm035451
• All: 1 reference(s)