Bcl2a1d^tm1.1Tac
Targeted Allele Detail

Summary

• Symbol: Bcl2a1d^tm1.1Tac
• Name: B cell leukemia/lymphoma 2 related protein A1d; targeted mutation 1.1, Taconic
• MGI ID: MGI:6272376
• Gene: Bcl2a1d Location: Chr9:88605341-88613903 bp, - strand Genetic Position: Chr9, 47.24 cM
• Alliance: Bcl2a1d^tm1.1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258915
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An approximately 2.5 kb region, including exon 1 and the upstream promoter, was replaced with an FRT site, puro cassette, lox5171 site and an FRT site. Flp mediated recombination removed the insert leaving a single FRT site. Targeting was done in ES cells carrying Bcl2a1a^tm1Tac (J:258915)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2a1d Mutation: 15 strains or lines available

References

• Original: J:258915 Schenk RL, et al., Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment. Cell Death Differ. 2017 Mar;24(3):534-545
• All: 4 reference(s)