About   Help   FAQ
Cr2M1Btlr
Chemically induced Allele Detail
Summary
Symbol: Cr2M1Btlr
Name: complement receptor 2; mutation 1, Bruce Beutler
MGI ID: MGI:6268702
Synonyms: Pillar
Gene: Cr2  Location: Chr1:194819119-194859024 bp, - strand  Genetic Position: Chr1, 98.44 cM
Alliance: Cr2M1Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsENU-induced T to A transversion at base pair 195,155,888 (v38) on chromosome 1, or base pair 21,303 in the GenBank genomic region NC_000067 encoding Cr2. The mutation corresponds to residue 2,244 in the mRNA sequence NM_007758 within exon 12 of 19 total exons. The mutation results in substitution of cysteine 713 to a premature stop codon (C713*) in the CR2 protein. (J:267527)
Inheritance:    Semidominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cr2 Mutation:  84 strains or lines available
References
Original:  J:267527 Choi JH, et al., Mutagenetix entry for Pillar. MGI Direct Data Submission. 2018;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory