Adamts20^m9Btlr
Chemically induced Allele Detail

Summary

• Symbol: Adamts20^m9Btlr
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 20; mutation 9, Bruce Beutler
• MGI ID: MGI:6268396
• Synonyms: whopper
• Gene: Adamts20 Location: Chr15:94166177-94329966 bp, - strand Genetic Position: Chr15, 48.2 cM
• Alliance: Adamts20^m9Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to T transversion at base pair 94,347,810 (v38) on chromosome 15, or base pair 84,265 in the GenBank genomic region NC_000081. The mutation corresponds to residue 1,871 in the mRNA sequence NM_177431 (isoform 1) within exon 12 of 39 total exons. The mutation results in a cysteine to phenylalanine substitution at position 537 (C537F) in the ADAMTS-20 protein. (J:267488)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts20 Mutation: 93 strains or lines available

References

• Original: J:267488 Prince L, et al., Mutagenetix entry for whopper. MGI Direct Data Submission. 2018
• All: 1 reference(s)