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Gpr108tm1.1Brs
Targeted Allele Detail
Nomenclature
Symbol: Gpr108tm1.1Brs
Name: G protein-coupled receptor 108; targeted mutation 1.1, Brian Seed
MGI ID: MGI:6267426
Gene: Gpr108  Location: Chr17:57234635-57248446 bp, - strand  Genetic Position: Chr17, 29.74 cM, cytoband E1.1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:266821
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn attB and attP-flanked neomycin resistance cassette replaced 17 exons and 2 kb upstream. R4 integrase expression removed the selection cassette. RT-PCR confirmed the absence of transcript expression in spleen and lungs. (J:266821)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpr108 Mutation:  5 strains or lines available
References
Original:  J:266821 Dong D, et al., GPR108, an NF-kappaB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. PLoS One. 2018;13(10):e0205303
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory