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Tg(Myh6-Tpm1*D230N)HJcf
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-Tpm1*D230N)HJcf
Name: transgene insertion H, Jil C Tardiff
MGI ID: MGI:6256754
Synonyms: D230N-high
Transgene: Tg(Myh6-Tpm1*D230N)HJcf  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Tpm1*D230N)HJcf expresses 1 gene
 
Mutation detailsThe alpha-tropoyosin containing a substitution of an aspartic acid for asparagine at residue 230 (D230N) is under the control of the cardiac specific rat alpha-myosin heavy chain promoter. This is the high-expressing line that expresses about 69% of the total Tpm1 as the mutant transgenic form. (J:243724)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:243724 Lynn ML, et al., The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy. J Mol Cell Cardiol. 2017 Jul;108:127-137
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory