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Endonuclease-mediated Allele Detail
Symbol: Del(13Naip1-Naip5)1Vnce
Name: deletion, Chr 13, Russell Vance 1
MGI ID: MGI:6246513
Synonyms: Naip1-6delta
Gene: Del(13Naip1-Naip5)1Vnce  Location: Chr13:100382831-100544278 bp  Genetic Position: Chr13, Syntenic
Strain of Origin:  B6(Cg)-Tyrc-2J/J
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(13Naip1-Naip5)1Vnce involves 4 genes/genome features (Naip5, Naip6, Naip3 ...) View all
Mutation detailsA single guide RNA (sgRNA; sequence GGTCAGAAGAGAATTACCTA) with protospacer adjacent motif (PAM; sequence TGG) targeted Cas9 to a 20-nucleotide sequence in exon 6 (the fourth coding exon) in each of the four functional mouse Naip genes (Naip1, 2, 5, and 6). The sequence between Naip5 exon 6 and Naip1 exon 6 was deleted including Naip3 and Naip6, leading to a nonfunctional fusion of Naip5 and Naip1. (J:233320)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Del(13Naip1-Naip5)1Vnce Mutation:  1 strain or line available
Original:  J:233320 Rauch I, et al., NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. J Exp Med. 2016 May 2;213(5):657-65
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory