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Pla2g6tm1a(EUCOMM)Wtsi
Targeted Allele Detail
Summary
Symbol: Pla2g6tm1a(EUCOMM)Wtsi
Name: phospholipase A2, group VI; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:6209669
Gene: Pla2g6  Location: Chr15:79170428-79212590 bp, - strand  Genetic Position: Chr15, 37.7 cM
Alliance: Pla2g6tm1a(EUCOMM)Wtsi page
IMPC: Pla2g6 gene page
Mutation
origin
Mutant Cell Line:  Pla2g6-G04
Germline Transmission:  Earliest citation of germline transmission: J:82809
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe Pla2g6-G04_tv cassette was inserted upstream of the critical exon 6 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 9. The critical exon 6 through 8 are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:82809)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pla2g6 Mutation:  65 strains or lines available
References
Original:  J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory