About   Help   FAQ
Endonuclease-mediated Allele Detail
Symbol: Mthfrem1Adiuj
Name: methylenetetrahydrofolate reductase; endonuclease-mediated mutation 1, MODEL-AD Center
MGI ID: MGI:6202965
Gene: Mthfr  Location: Chr4:148039077-148059551 bp, + strand  Genetic Position: Chr4, 78.67 cM
Strain of Origin:  B6(SJL)-Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J
Allele Type:    Endonuclease-mediated (Not Specified)
Mutation:    Nucleotide substitutions
Mutation detailsPlasmids encoding a single guide RNA designed to introduce a R47H point mutation into the gene and the cas9 nuclease were introduced into the cytoplasm of fertilized eggs with well recognized pronuclei. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mthfr Mutation:  25 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory