Notum^em150Sinn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Notum^em150Sinn
• Name: notum palmitoleoyl-protein carboxylesterase; endonuclease-mediated mutation 150, Debora Sinner
• MGI ID: MGI:6200803
• Synonyms: Notum1-123, Notum¹⁵⁰
• Gene: Notum Location: Chr11:120544614-120552001 bp, - strand Genetic Position: Chr11, 84.38 cM
• Alliance: Notum^em150Sinn page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mediated recombination created a 158 bp deletion in the region between exons 3 and 4 resulting in a premature stop codon. (J:260471)

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notum Mutation: 28 strains or lines available

References

• Original: J:260471 Gerhardt B, et al., Notum attenuates Wnt/beta-catenin signaling to promote tracheal cartilage patterning. Dev Biol. 2018 Apr 1;436(1):14-27
• All: 1 reference(s)