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Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Russell E Vance
MGI ID: MGI:6196853
Synonyms: iOvaFla
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:260047
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Mutation detailsA construct encoding a loxP-flanked transcriptional STOP cassette upstream of chicken ovalbumin lacking its signal sequence fused to the C-terminal 166 amino acids of Legionella pneumophila flagellin and an IRES-GFP downstream of the fusion gene was targeted to the locus. This creates a conditional-ready allele that will only be expressed after cre-mediated deletion of the STOP cassette. Expression of flagellin activates endogenous NAIP/NLLRC4 inflammasome while the ovalbumin permits the tracking of the adaptive immune response. (J:260047)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  523 strains or lines available
References
Original:  J:260047 Nichols RD, et al., NAIP/NLRC4 inflammasome activation in MRP8(+) cells is sufficient to cause systemic inflammatory disease. Nat Commun. 2017 Dec 20;8(1):2209
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory