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Targeted Allele Detail
Symbol: Klra1tm1.1Wyok
Name: killer cell lectin-like receptor, subfamily A, member 1; targeted mutation 1.1, Wayne M Yokoyama
MGI ID: MGI:6196148
Synonyms: AYF
Gene: Klra1  Location: Chr6:130340881-130363837 bp, - strand  Genetic Position: Chr6, 63.44 cM
Germline Transmission:  Earliest citation of germline transmission: J:252851
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Single point mutation
Mutation detailsA loxP site flanked neomycin resistance gene cassette was inserted into intron 4. A substitution was engineered in exon 4 that changed codon 8 from tyrosine to phenylalanine (p.Tyr8Phe or p.Y8F). This mutation disrupts the cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) of the peptide, effectively creating a knock-out. The neo cassette was removed through subsequent cre-mediated recombination. (J:252851)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klra1 Mutation:  14 strains or lines available
Original:  J:252851 Bern MD, et al., Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8440-E8447
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory