Gt(ROSA)26Sortm1(CAG-MYCN,-luc)Jhsc
Targeted Allele Detail
|
Symbol: |
Gt(ROSA)26Sortm1(CAG-MYCN,-luc)Jhsc |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Johannes H Schulte |
MGI ID: |
MGI:6196127 |
Synonyms: |
LSL-MYCN |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
|
Alliance: |
Gt(ROSA)26Sortm1(CAG-MYCN,-luc)Jhsc page
|
|
|
Allele Type: |
|
Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, RMCE-ready, Reporter) |
Mutation: |
|
Insertion
|
|
|
Gt(ROSA)26Sortm1(CAG-MYCN,-luc)Jhsc expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MYCN (4613) |
|
|
|
|
|
Mutation details: Recombinase-mediated cassette exchange (RMCE) replaced the selection cassette in Gt(ROSA)26Sortm1(CAG-flpe)Arte with a 5' deleted neomycin resistance cassette, the chicken actin gene (CAG) promoter, loxP flanked strong transcriptional termination site (LSL), the human MYCN gene, IRES, and the firefly luciferase gene. Cre-mediated recombination can be utilized to remove the transcription termination site 5' to the MYCN allele to get MYCN expression.
(J:222527)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Gt(ROSA)26Sor Mutation: |
942 strains or lines available
|
|
Original: |
J:222527 Althoff K, et al., A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies. Oncogene. 2015 Jun;34(26):3357-68 |
All: |
7 reference(s) |
|