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Tg(GFAP-ATXN7*92Q)2542Als
Transgene Detail
Nomenclature
Symbol: Tg(GFAP-ATXN7*92Q)2542Als
Name: transgene insertion 2542, Albert La Spada
MGI ID: MGI:6194622
Synonyms: Gfa2-SCA7-92Q line 2,542
Transgene: Tg(GFAP-ATXN7*92Q)2542Als  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x C3H/HeJ)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(GFAP-ATXN7*92Q)2542Als expresses 1 gene
 
Mutation detailsA 2.2-kb human glial fibrillary acidic protein fragment of the promotor region drives the expression of a flag and c-myc tagged human ataxin-7 cDNA bearing 92 glutamines. Western blot analysis confirmed expression of the transgene. Immunostaining confirmed that expression is restricted to regions of the cerebellum in which Bergmann glia reside and is probably nuclear and cytosolic. This is the high expressing line. (J:113150)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:113150 Custer SK, et al., Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nat Neurosci. 2006 Oct;9(10):1302-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory