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Klhl14tm1.1Jyw
Targeted Allele Detail
Nomenclature
Symbol: Klhl14tm1.1Jyw
Name: kelch-like 14; targeted mutation 1.1, Ji-Yang Wang
MGI ID: MGI:6191749
Gene: Klhl14  Location: Chr18:21550377-21654718 bp, - strand  Genetic Position: Chr18, 11.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:263511
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 21626295 of Chromosome 18 upstream of the critical exon 3 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 21624205. Cre-mediated recombination removed exon 3 and the selection cassette leaving behind the reporter cassette. (J:263511)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klhl14 Mutation:  1 strain or line available
References
Original:  J:263511 Li S, et al., Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development. Int Immunol. 2018 Jun 26;30(7):311-318
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory