Lrrtm1^tm1.1Rmlk
Targeted Allele Detail

Summary

• Symbol: Lrrtm1^tm1.1Rmlk
• Name: leucine rich repeat transmembrane neuronal 1; targeted mutation 1.1, Robert Malenka
• MGI ID: MGI:6188307
• Synonyms: LRRTM1^flox
• Gene: Lrrtm1 Location: Chr6:77219672-77234774 bp, + strand Genetic Position: Chr6, 33.89 cM
• Alliance: Lrrtm1^tm1.1Rmlk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263004
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted into intron 2. (J:263004)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrtm1 Mutation: 36 strains or lines available

References

• Original: J:263004 Bhouri M, et al., Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5382-E5389
• All: 2 reference(s)