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Atp1a2tm1.1Tmklh
Targeted Allele Detail
Nomenclature
Symbol: Atp1a2tm1.1Tmklh
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide; targeted mutation 1.1, Karin Lykke-Hartmann
MGI ID: MGI:6187668
Synonyms: alpha2G301R
Gene: Atp1a2  Location: Chr1:172271709-172298064 bp, - strand  Genetic Position: Chr1, 79.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:259556
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsThe targeting construct introduced a G to A mutation in exon 8 that results in the amino acid substitution of arginine for glycine at position 301 (G301R). Cre-mediated recombination removed a neomycin resistance cassette inserted into intron 7. (J:259556)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 26 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp1a2 Mutation:  2 strains or lines available
References
Original:  J:259556 Bottger P, et al., Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. Sci Rep. 2016 Feb 25;6:22047
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory