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Clcnkbem1Haca
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Clcnkbem1Haca
Name: chloride channel, voltage-sensitive Kb; endonuclease mediated mutation 1, Hayo Castrop
MGI ID: MGI:6164702
Synonyms: ClC-K2-
Gene: Clcnkb  Location: Chr4:141404353-141416014 bp, - strand  Genetic Position: Chr4, 74.02 cM, cytoband E1
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsTALEN-mediated mutagenesis resulted in an 11 bp deletion in exon 2, near the ATG initiation codon. The deletion resulted in a frame-shift and the introduction of a premature stop codon. (J:259681)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clcnkb Mutation:  16 strains or lines available
References
Original:  J:259681 Grill A, et al., Salt-losing nephropathy in mice with a null mutation of the Clcnk2 gene. Acta Physiol (Oxf). 2016 Nov;218(3):198-211
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory