Mir133a-1hg^tm2.1Thbr
Targeted Allele Detail

Summary

• Symbol: Mir133a-1hg^tm2.1Thbr
• Name: Mir133a-1, Mir1b and Mir1a-2 host gene; targeted mutation 2.1, Thomas Braun
• MGI ID: MGI:6164312
• Synonyms: miR-1-2/133a-1^fl
• Gene: Mir133a-1hg Location: Chr18:10781718-10787773 bp, - strand Genetic Position: Chr18, Syntenic
• Alliance: Mir133a-1hg^tm2.1Thbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262205
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of Mir1a-2 and an FRT flanked neo cassette and loxP site were inserted downstream of Mir133a-1 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:262205)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir133a-1hg Mutation: 0 strains or lines available

References

• Original: J:262205 Wust S, et al., Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster. Cell Metab. 2018 May 1;27(5):1026-1039.e6
• All: 3 reference(s)