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Atp1a3tm1.1Tmklh
Targeted Allele Detail
Nomenclature
Symbol: Atp1a3tm1.1Tmklh
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide; targeted mutation 1.1, Karin Lykke-Hartmann
MGI ID: MGI:6163502
Synonyms: alpha3D801Y, Atp1a3tm1Klh
Gene: Atp1a3  Location: Chr7:24978167-25005958 bp, - strand  Genetic Position: Chr7, 13.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:254463
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 17 was replaced with a floxed neomycin resistance cassette and a modified exon 17 in which nucleotide substitution (G to T) results in the amino acid substitution of tyrosine for aspartic acid (D801Y). Cre-mediated recombination removed the selection cassette. (J:254463)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp1a3 Mutation:  39 strains or lines available
References
Original:  J:254463 Holm TH, et al., Cognitive deficits caused by a disease-mutation in the alpha3 Na(+)/K(+)-ATPase isoform. Sci Rep. 2016 Aug 23;6:31972
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory