Mecp2^em1Dkatz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mecp2^em1Dkatz
• Name: methyl CpG binding protein 2; endonuclease-mediated mutation 1, David Katz
• MGI ID: MGI:6158911
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^em1Dkatz page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 methodologies were used to delete 698 bp deletion in exon 3. Protein expression is significantly reduced (by approximately 50% or more) as detected by western blot analysis of brain tissue from heterozygous female mice. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 38 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)