Plin3^tm1.1Jbki
Targeted Allele Detail

Summary

• Symbol: Plin3^tm1.1Jbki
• Name: perilipin 3; targeted mutation 1.1, Jae Bum Kim
• MGI ID: MGI:6158435
• Gene: Plin3 Location: Chr17:56585962-56597511 bp, - strand Genetic Position: Chr17, 29.25 cM, cytoband D
• Alliance: Plin3^tm1.1Jbki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261132
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were introduced downstream of exon 5 via homologous recombination. Cre mediated recombination removed exons 3 - 5 and the neo cassette. (J:261132)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plin3 Mutation: 64 strains or lines available

References

• Original: J:261132 Lee YK, et al., Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARalpha Activation. Diabetes. 2018 May;67(5):791-804
• All: 1 reference(s)