About   Help   FAQ
2610301B20Rikem3Jyang
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: 2610301B20Rikem3Jyang
Name: RIKEN cDNA 2610301B20 gene; endonuclease-mediated mutation 3, Jun Yang
MGI ID: MGI:6157831
Synonyms: C8orf37del
Gene: 2610301B20Rik  Location: Chr4:10874498-10899425 bp, + strand  Genetic Position: Chr4, 4.85 cM
Mutation
origin
Strain of Origin:  CBA x C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA large deletion encompassing exons 1 - 5 including the translation start codon was generated through CRISPR/cas9 mediated recombination. Immunoblot analysis demonstrated the absence of protein expression in homozygous mice. (J:259133)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any 2610301B20Rik Mutation:  2 strains or lines available
Notes
founders do not carry Crb1
References
Original:  J:259133 Sharif AS, et al., C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis. J Neurosci. 2018 Mar 28;38(13):3160-3176
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory