Dpp9^tm1.1Npa
Targeted Allele Detail

Summary

• Symbol: Dpp9^tm1.1Npa
• Name: dipeptidylpeptidase 9; targeted mutation 1.1, Novartis Pharma AG
• MGI ID: MGI:6157525
• Synonyms: DPP9^ki
• Gene: Dpp9 Location: Chr17:56493807-56525905 bp, - strand Genetic Position: Chr17, 29.2 cM
• Alliance: Dpp9^tm1.1Npa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251322
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 18 was replaced with a modified on in which nucleotide substitutions result in the amino acid substitution of alanine for serine at position 749 (S749A). This mutation is predicted to cause the loss of enzyme activity. Flp-mediated recombination removed an FRT-flanked neomycin resistance cassette. (J:251322)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpp9 Mutation: 62 strains or lines available

References

• Original: J:251322 Kim M, et al., DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect. Dev Biol. 2017 Nov 15;431(2):297-308
• All: 2 reference(s)