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Manftm1c(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Manftm1c(KOMP)Wtsi
Name: mesencephalic astrocyte-derived neurotrophic factor; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:6157444
Synonyms: Manffl, Manfflox
Gene: Manf  Location: Chr9:106887415-106891938 bp, - strand  Genetic Position: Chr9, 57.98 cM, cytoband F1
Mutation
origin
Mutant Cell Line:  EPD0162_3_D06
Germline Transmission:  Earliest citation of germline transmission: J:211812
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 106890641 of Chromosome 9 upstream of exon 3 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 3 at position 106889952. A "conditional ready" (floxed) allele was created through flp-mediate recombination, leaving exon 3 floxed. (J:211812)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Manf Mutation:  4 strains or lines available
References
Original:  J:211812 Lindahl M, et al., MANF is indispensable for the proliferation and survival of pancreatic beta cells. Cell Rep. 2014 Apr 24;7(2):366-75
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory