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Marveld2tm1Sats
Targeted Allele Detail
Summary
Symbol: Marveld2tm1Sats
Name: MARVEL (membrane-associating) domain containing 2; targeted mutation 1, Sachiko Tsukita
MGI ID: MGI:6156852
Synonyms: Tric-
Gene: Marveld2  Location: Chr13:100732465-100753479 bp, - strand  Genetic Position: Chr13, 53.23 cM
Alliance: Marveld2tm1Sats page
Progressive degeneration of hair cells in the organ of Corti of Marveld2tm1Sats/Marveld2tm1Sats mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:261357
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP-flanked PGK-Neo cassette replaced exon 2. Western blot analysis confirmed the absence of protein in homozygotes. (J:261357)
Generation of the Marveld2tm1Sats allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Marveld2 Mutation:  29 strains or lines available
References
Original:  J:261357 Kamitani T, et al., Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells. Sci Rep. 2015 Dec 18;5:18402
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory