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Targeted Allele Detail
Symbol: Marveld2tm1Sats
Name: MARVEL (membrane-associating) domain containing 2; targeted mutation 1, Sachiko Tsukita
MGI ID: MGI:6156852
Synonyms: Tric-
Gene: Marveld2  Location: Chr13:100595957-100616971 bp, - strand  Genetic Position: Chr13, 53.23 cM
Progressive degeneration of hair cells in the organ of Corti of Marveld2tm1Sats/Marveld2tm1Sats mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:261357
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP-flanked PGK-Neo cassette replaced exon 2. Western blot analysis confirmed the absence of protein in homozygotes. (J:261357)
Generation of the Marveld2tm1Sats allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Marveld2 Mutation:  24 strains or lines available
Original:  J:261357 Kamitani T, et al., Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells. Sci Rep. 2015 Dec 18;5:18402
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory