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Stat2tm1.1(STAT2)Diam
Targeted Allele Detail
Nomenclature
Symbol: Stat2tm1.1(STAT2)Diam
Name: signal transducer and activator of transcription 2; targeted mutation 1.1, Michael S Diamond
MGI ID: MGI:6156567
Synonyms: hSTAT2 KI
Gene: Stat2  Location: Chr10:128270559-128292849 bp, + strand  Genetic Position: Chr10, 76.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:261503
Parent Cell Line:  ART B6 3.6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Stat2tm1.1(STAT2)Diam expresses 1 gene
 
Mutation detailsThe targeting vector was created using mouse Stat2 sequences from C57BL/6J BAC RPCIB-731 and human STAT2 sequences from human BAC RPCIB-753. The targeting vector also inserted an FRT-flanked neomycin resistance cassette in intron 1 and a F3-flanked puromycin resistance cassette in intron 24. The vector is designed replace the endogenous mouse Stat2 coding sequence (spanning from part of exon 2 through part of exon 24) with the corresponding human STAT2 coding sequence. The allele retains the endogenous mouse Stat2 5' untranslated region, promoter sequences (exon 1 and part of exon 2) and 3' untranslated region. Flp-mediated recombination removed the FRT-flanked neo and puro cassettes. (J:261503)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stat2 Mutation:  8 strains or lines available
References
Original:  J:261503 Gorman MJ, et al., An Immunocompetent Mouse Model of Zika Virus Infection. Cell Host Microbe. 2018 May 9;23(5):672-685.e6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory