Stat2^{tm1.1(STAT2)Diam}
Targeted Allele Detail

Summary

• Symbol: Stat2^{tm1.1(STAT2)Diam}
• Name: signal transducer and activator of transcription 2; targeted mutation 1.1, Michael S Diamond
• MGI ID: MGI:6156567
• Synonyms: hSTAT2 KI
• Gene: Stat2 Location: Chr10:128106428-128128718 bp, + strand Genetic Position: Chr10, 76.5 cM
• Alliance: Stat2^{tm1.1(STAT2)Diam} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261503
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Stat2^{tm1.1(STAT2)Diam} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  STAT2 (6773)

  Stat2

  (MGI:103039)

• Mutation details: The targeting vector was created using mouse Stat2 sequences from C57BL/6J BAC RPCIB-731 and human STAT2 sequences from human BAC RPCIB-753. The targeting vector also inserted an FRT-flanked neomycin resistance cassette in intron 1 and a F3-flanked puromycin resistance cassette in intron 24. The vector is designed replace the endogenous mouse Stat2 coding sequence (spanning from part of exon 2 through part of exon 24) with the corresponding human STAT2 coding sequence. The allele retains the endogenous mouse Stat2 5' untranslated region, promoter sequences (exon 1 and part of exon 2) and 3' untranslated region. Flp-mediated recombination removed the FRT-flanked neo and puro cassettes. (J:261503)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stat2 Mutation: 35 strains or lines available

References

• Original: J:261503 Gorman MJ, et al., An Immunocompetent Mouse Model of Zika Virus Infection. Cell Host Microbe. 2018 May 9;23(5):672-685.e6
• All: 4 reference(s)