Eif4a3^tm1.1Dlsi
Targeted Allele Detail

Summary

• Symbol: Eif4a3^tm1.1Dlsi
• Name: eukaryotic translation initiation factor 4A3; targeted mutation 1.1, Debra L Silver
• MGI ID: MGI:6155638
• Synonyms: Eif4a3^lox
• Gene: Eif4a3 Location: Chr11:119179189-119190869 bp, - strand Genetic Position: Chr11, 83.35 cM
• Alliance: Eif4a3^tm1.1Dlsi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235650
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a FRT-flanked neomycin resistance cassette and a second loxP site were inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette, leaving exon 2 floxed. (J:235650)

Expression

In Mice Carrying this Mutation:	20 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif4a3 Mutation: 9 strains or lines available

References

• Original: J:235650 Mao H, et al., Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS Genet. 2016 Sep;12(9):e1006282
• All: 2 reference(s)