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Trip11tm1.1Psmi
Targeted Allele Detail
Nomenclature
Symbol: Trip11tm1.1Psmi
Name: thyroid hormone receptor interactor 11; targeted mutation 1.1, Patrick Smits
MGI ID: MGI:6154012
Synonyms: Trip11cko
Gene: Trip11  Location: Chr12:101834045-101913171 bp, - strand  Genetic Position: Chr12, 51.3 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:253969
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted 671 bp upstream of exon 1 (which contains the ATG) and an FRT site-flanked neomycin selection cassette immediately followed by a loxP site was placed 1506 bp downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 1 floxed. (J:253969)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trip11 Mutation:  61 strains or lines available
References
Original:  J:253969 Bird IM, et al., The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects. Development. 2018 Jan 8;145(1)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory