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Fat1tm1.1Nsib
Targeted Allele Detail
Nomenclature
Symbol: Fat1tm1.1Nsib
Name: FAT atypical cadherin 1; targeted mutation 1.1, Nicholas Sibinga
MGI ID: MGI:6153609
Synonyms: Fat1fl, Fat1loxP, Fat1tm1.1Atuf
Gene: Fat1  Location: Chr8:45388484-45505294 bp, + strand  Genetic Position: Chr8, 24.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234732
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 2 was flanked by loxP sites and a FRT-flanked neomycin selection cassette was inserted. Flp-mediated recombination removed the selection cassette, leaving exon 2 floxed. (J:234732)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fat1 Mutation:  137 strains or lines available
References
Original:  J:234732 Gee HY, et al., FAT1 mutations cause a glomerulotubular nephropathy. Nat Commun. 2016;7:10822
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory