Mlkl^tm1Tac
Targeted Allele Detail

Summary

• Symbol: Mlkl^tm1Tac
• Name: mixed lineage kinase domain-like; targeted mutation 1, Taconic
• MGI ID: MGI:6144429
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^tm1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258144
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A selection cassette replaced several exons of the gene. (J:258144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 32 strains or lines available

References

• Original: J:258144 Yoon S, et al., MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity. 2017 Jul 18;47(1):51-65.e7
• All: 1 reference(s)