About   Help   FAQ
Ndufa1tm1.1Nay
Targeted Allele Detail
Nomenclature
Symbol: Ndufa1tm1.1Nay
Name: NADH:ubiquinone oxidoreductase subunit A1; targeted mutation 1.1, Nagendra Yadava
MGI ID: MGI:6140203
Synonyms: Ndufa1S55A
Gene: Ndufa1  Location: ChrX:37187588-37191163 bp, - strand  Genetic Position: ChrX, 21.61 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:257477
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Nucleotide substitutions
 
Mutation detailsThe targeting vector is designed to substitute an alanine for serine at codon 55 (S55A) by introducing a point mutation (c.163 TCT to GCT). The mutation is located in exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:257477)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ndufa1 Mutation:  0 strains or lines available
References
Original:  J:257477 Kim C, et al., An X-chromosome linked mouse model (Ndufa1(S55A)) for systemic partial Complex I deficiency for studying predisposition to neurodegeneration and other diseases. Neurochem Int. 2017 Oct;109:78-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/03/2019
MGI 6.14
The Jackson Laboratory