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Tafa3em1Hssh
Endonuclease-mediated Allele Detail
Summary
Symbol: Tafa3em1Hssh
Name: TAFA chemokine like family member 3; endonuclease-mediated mutation 1, Hee-Sup Shin
MGI ID: MGI:6140086
Synonyms: Sam3-
Gene: Tafa3  Location: Chr3:104674721-104686854 bp, - strand  Genetic Position: Chr3, 45.84 cM, cytoband F2.2
Alliance: Tafa3em1Hssh page
Mutation
origin
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA TALEN-mediated mutation was produced by targeting exon 4, which contains the initiation codon ATG. A 43-bp deletion from this genomic region was confirmed by sequencing, resulting in a frameshift mutation with a premature stop codon. RT-PCR analysis confirmed the absence of mRNA expression in whole brain lysates without the hippocampus as well as in hippocampus only lysates from homozygous mutant mice. (J:257371)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tafa3 Mutation:  6 strains or lines available
References
Original:  J:257371 Kim S, et al., Deficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice. Sci Rep. 2017 Nov 28;7(1):16503
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory