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Targeted Allele Detail
Symbol: Nr1h4tm1.2Gonz
Name: nuclear receptor subfamily 1, group H, member 4; targeted mutation 1.2, Frank Gonzalez
MGI ID: MGI:6121372
Synonyms: Fxrfl
Gene: Nr1h4  Location: Chr10:89290096-89369447 bp, - strand  Genetic Position: Chr10, 44.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe targeting construct contains a loxP site inserted in the intron 5' to the last exon and a loxP-flanked neomycin cassette inserted 3' to the last exon. Germline Cre-mediated recombination removed the floxed neo cassette leaving the last exon floxed. The last exon encodes the ligand binding domain and all of the 3' untranslated region. (J:64792)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr1h4 Mutation:  27 strains or lines available
The version of this allele that contains the neomycin selection cassette, Nr1h4tm1.1Gonz, has been analyzed.
Original:  J:64792 Sinal CJ, et al., Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 2000 Sep 15;102(6):731-44
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory