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Targeted Allele Detail
Symbol: Dstyktm1.2Zlh
Name: dual serine/threonine and tyrosine protein kinase; targeted mutation 1.2, Ze-Lan Hu
MGI ID: MGI:6121070
Gene: Dstyk  Location: Chr1:132417555-132466958 bp, + strand  Genetic Position: Chr1, 57.24 cM, cytoband E4
Germline Transmission:  Earliest citation of germline transmission: J:226871
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA loxP site was inserted into intron 3 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 13. The neo cassette was removed through subsequent flp-mediated recombination. Exons 4-13 were deleted through subsequent cre-mediated recombination. Exons 8-13 code for the kinase domain. qRT-PCR and western blots confirmed the absence of expression from this allele. (J:226871)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dstyk Mutation:  17 strains or lines available
Original:  J:226871 Li K, et al., DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test. Int J Clin Exp Pathol. 2014;7(10):6486-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory