Gt(ROSA)26Sor^{tm1(Rnf146)Vdaw}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Rnf146)Vdaw}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Valina Dawson
• MGI ID: MGI:6120897
• Synonyms: Rnf146^loxP, ROSA26PA-Iduna
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Rnf146)Vdaw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257410
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Rnf146)Vdaw} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rnf146 (MGI:1915281)

• Mutation details: A floxed neo cassette and mouse Rnf146 cDNA were inserted into the locus via homologous recombination. (J:257410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 945 strains or lines available

References

• Original: J:257410 Andrabi SA, et al., Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. Nat Med. 2011 Jun;17(6):692-9
• All: 2 reference(s)