Amotl2^tm1.1Laho
Targeted Allele Detail

Summary

• Symbol: Amotl2^tm1.1Laho
• Name: angiomotin-like 2; targeted mutation 1.1, Lars Holmgren
• MGI ID: MGI:6120889
• Synonyms: amotL2^lox
• Gene: Amotl2 Location: Chr9:102594290-102610616 bp, + strand Genetic Position: Chr9, 54.71 cM
• Alliance: Amotl2^tm1.1Laho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226656
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an F3 site flanked puromycin resistance gene cassette and a second loxP site into intron 3. The puro cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 3 floxed. (J:226656)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amotl2 Mutation: 54 strains or lines available

References

• Original: J:226656 Hultin S, et al., AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. Nat Commun. 2014;5:3743
• All: 2 reference(s)