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Tagln2tm1Cdj
Targeted Allele Detail
Nomenclature
Symbol: Tagln2tm1Cdj
Name: transgelin 2; targeted mutation 1, Chang-Duk Jun
MGI ID: MGI:6118987
Gene: Tagln2  Location: Chr1:172500246-172507375 bp, + strand  Genetic Position: Chr1, 79.89 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:256656
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a floxed MC1-neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in homozygous mice. (J:256656)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tagln2 Mutation:  10 strains or lines available
References
Original:  J:256656 Na BR, et al., TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. J Cell Biol. 2015 Apr 13;209(1):143-62
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory