Tagln2^tm1Cdj
Targeted Allele Detail

Summary

• Symbol: Tagln2^tm1Cdj
• Name: transgelin 2; targeted mutation 1, Chang-Duk Jun
• MGI ID: MGI:6118987
• Gene: Tagln2 Location: Chr1:172327813-172334942 bp, + strand Genetic Position: Chr1, 79.89 cM
• Alliance: Tagln2^tm1Cdj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256656
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a floxed MC1-neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in homozygous mice. (J:256656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tagln2 Mutation: 20 strains or lines available

References

• Original: J:256656 Na BR, et al., TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. J Cell Biol. 2015 Apr 13;209(1):143-62
• All: 4 reference(s)