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Tg(H2-Ea-HLA-DRB1*0401*)1Dv
Transgene Detail
Nomenclature
Symbol: Tg(H2-Ea-HLA-DRB1*0401*)1Dv
Name: transgene insertion 1, Chella David
MGI ID: MGI:6117040
Synonyms: DR4beta(NT)
Transgene: Tg(H2-Ea-HLA-DRB1*0401*)1Dv  Location: unknown  
Transgene
origin
Strain of Origin:  (SWR x C57BL/10)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene has the mouse H2-Ealpha promoter (and rabbit beta-globin intron) upstream of a human HLA-DRB1*0401 cDNA sequence engineered to have amino acid mutations (Q110N and K139T) in the beta2 domain to provide an improved interaction with murine CD4. (J:134781)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:134781 Pan S, et al., HLA-DR4 (DRB1*0401) transgenic mice expressing an altered CD4-binding site: specificity and magnitude of DR4-restricted T cell response. J Immunol. 1998 Sep 15;161(6):2925-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory