Jam2^{tm1.1(cre)Jrs}
Targeted Allele Detail

Summary

• Symbol: Jam2^{tm1.1(cre)Jrs}
• Name: junction adhesion molecule 2; targeted mutation 1.1, Joshua R Sanes
• MGI ID: MGI:6116683
• Synonyms: JAM-B Cre
• Gene: Jam2 Location: Chr16:84571011-84622816 bp, + strand Genetic Position: Chr16, 46.92 cM
• Alliance: Jam2^{tm1.1(cre)Jrs} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254378
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Jam2^{tm1.1(cre)Jrs} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Jam2 (MGI:1933820)

• Mutation details: Exon 1 was replaced with Cre recombinase and an FRT-flanked SV40-neomycin cassette in reverse transcriptional orientation. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:254378)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Jam2 (mouse) Summary of all recombinase alleles driven by Jam2. Alliance mouse Jam2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jam2 Mutation: 121 strains or lines available

References

• Original: J:254378 Liu J, et al., Cellular and Molecular Analysis of Dendritic Morphogenesis in a Retinal Cell Type That Senses Color Contrast and Ventral Motion. J Neurosci. 2017 Dec 13;37(50):12247-12262
• All: 2 reference(s)