Pi16^tm1.2Engl
Targeted Allele Detail

Summary

• Symbol: Pi16^tm1.2Engl
• Name: peptidase inhibitor 16; targeted mutation 1.2, Stefan Engelhardt
• MGI ID: MGI:6114785
• Gene: Pi16 Location: Chr17:29537770-29547876 bp, + strand Genetic Position: Chr17, 15.22 cM, cytoband B1
• Alliance: Pi16^tm1.2Engl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244259
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted into introns 2 and 4. An FRT site flanked neomycin resistance gene cassette was also inserted. Subsequent flp-mediated recombination removed the neo cassette, and cre-mediated recombination deleted exons 3 and 4. (J:244259)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pi16 Mutation: 29 strains or lines available

References

• Original: J:244259 Regn M, et al., Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. J Mol Cell Cardiol. 2016 Oct;99:57-64
• All: 2 reference(s)