Cdk20^tm1.1Jegg
Targeted Allele Detail

Summary

• Symbol: Cdk20^tm1.1Jegg
• Name: cyclin dependent kinase 20; targeted mutation 1.1, Jonathan Eggenschwiler
• MGI ID: MGI:6113512
• Gene: Cdk20 Location: Chr13:64580133-64587536 bp, + strand Genetic Position: Chr13, 33.26 cM
• Alliance: Cdk20^tm1.1Jegg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243907
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination deleted exons 1, 2 and the neo cassette. Western blot analysis confirmed the absenceof protein expression in homozygous null embryos. (J:243907)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk20 Mutation: 10 strains or lines available

References

• Original: J:243907 Snouffer A, et al., Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice. PLoS Genet. 2017 Aug;13(8):e1006912
• All: 3 reference(s)