Tex19.1^tm2.2Ics
Targeted Allele Detail

Summary

• Symbol: Tex19.1^tm2.2Ics
• Name: testis expressed gene 19.1; targeted mutation 2.2, Mouse Clinical Institute
• MGI ID: MGI:6110011
• Gene: Tex19.1 Location: Chr11:121036969-121039140 bp, + strand Genetic Position: Chr11, 85.0 cM
• Alliance: Tex19.1^tm2.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243444
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. A Loxp and FRT site flanked neomycin resistance gene cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exons 1-3 containing the coding sequence. Western blot analysis confirmed the absence of protein expression in ES cells and testis. (J:243444)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tex19.1 Mutation: 10 strains or lines available

References

• Original: J:243444 Tarabay Y, et al., Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression. J Cell Sci. 2017 Apr 15;130(8):1463-1474
• All: 1 reference(s)