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Shprhtm1Jhjh
Targeted Allele Detail
Nomenclature
Symbol: Shprhtm1Jhjh
Name: SNF2 histone linker PHD RING helicase; targeted mutation 1, Jan H J Hoeijmakers
MGI ID: MGI:6108184
Gene: Shprh  Location: Chr10:11149427-11217595 bp, + strand  Genetic Position: Chr10, 3.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177630
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene cassette replaced exons 9 and 10. Immunoblots confirm the lack of expression of wild-type peptide from this allele. (J:177630)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shprh Mutation:  4 strains or lines available
References
Original:  J:177630 Krijger PH, et al., HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase. DNA Repair (Amst). 2011 Apr 3;10(4):438-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory