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Tg(C9orf72*)19Lagi
Transgene Detail
Nomenclature
Symbol: Tg(C9orf72*)19Lagi
Name: transgene insertion 19, Clotilde Lagier-Tourenne
MGI ID: MGI:6100942
Synonyms: C919
Transgene: Tg(C9orf72*)19Lagi  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x C3H
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(C9orf72*)19Lagi expresses 1 gene
 
Mutation detailsThe transgenic construct is constructed with a ~156 kbp human bacterial artificial chromosome (BAC) CH523-111K12 (Chr9:27,561,110-27,714,308; May 2016) containing the human C9ALS patient-derived C9orf72 gene encoding a truncated short C9ORF72 isoform (222 aa; exons 1-5 with TAA site and polyA signal) with hexanucleotide repeat expansions (GGGGCC) in intron 1a. The BAC has ~140 kbp of transcriptionally-upstream (telomeric) flanking sequences that contain no other confirmed genes. Founder line C9<19> (called line 19) was identified with multiple transgene copies at the same locus that segregate together - with each transgene copy containing either ~90 or ~450 hexanucleotide repeat lengths. (J:232242)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:232242 Jiang J, et al., Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 May 4;90(3):535-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory