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Tuba8tm1.2Ctpd
Targeted Allele Detail
Nomenclature
Symbol: Tuba8tm1.2Ctpd
Name: tubulin, alpha 8; targeted mutation 1.2, Christine P Diggle
MGI ID: MGI:6094271
Gene: Tuba8  Location: Chr6:121210734-121226098 bp, + strand  Genetic Position: Chr6, 57.15 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:248203
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neomycin with a 5' lox site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 3. Immunohistochemistry confirmed the absence of protein expression in the testes and brain. (J:248203)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 38 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tuba8 Mutation:  18 strains or lines available
References
Original:  J:248203 Diggle CP, et al., A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development. PLoS One. 2017;12(4):e0174264
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory